CMRB - CMR[B] Centro de Medicina Regenerativa de Barcelona

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Publicaciones

2011

Bilic J, Izpisúa Belmonte JC. (2012) Concise review: induced pluripotent stem cells versus embryonic stem cells: close enough or yet too far apart?
Stem Cells 30(1): 33-41.
Camus S, Quevedo C, Menéndez S, Paramonov I, Stouten PF, Janssen RA, Rueb S, He S, Snaar-Jagalska BE, Laricchia-Robbio L, Izpisúa Belmonte JC. (2011) Identification of phosphorylase kinase as a novel therapeutic target through high-throughput screening for anti-angiogenesis compounds in zebrafish.
Oncogene, Dec 19. [Epub ahead of print]
Liu G-H, Sancho-Martinez I, and Izpisúa Belmonte JC. (2011) Cut and Paste: restoring cellular function by gene correction.
Cell Research Dec 6. [Epub ahead of print].
Tiscornia G, Lorenzo Vivas E, Izpisúa Belmonte JC. (2011) Diseases in a Dish: modeling human disease with induced pluripotent stem cells.
Nature Medicine Dec 6: 1570-1576.
Li M, Suzuki K, Qu J, Saini P, Dubova I, Yi F, Lee J, Sancho-Martinez I, Liu GH, Izpisúa Belmonte JC. (2011) Efficient correction of hemoglobinopathy-causing mutations by homologous recombination in integration-free patient iPSCs.
Cell Res. 21(12): 1740-4.
Sancho-Martinez I, Nivet E, Izpisúa Belmonte JC. (2011) The labyrinth of nuclear reprogramming.
J Mol Cell Biol. 3(6): 327-9.
Panopoulos AD, Yanes O, Ruiz S, Kida YS, Diep D, Tautenhahn R, Herrerías A, Batchelder EM, Plongthongkum N, Lutz M, Berggren WT, Zhang K, Evans RM, Siuzdak G, Izpisúa Belmonte JC. (2011) The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming.
Cell Res. Nov 8. [Epub ahead of print]
Sancho-Martinez I, Nivet E, Izpisúa Belmonte JC. (2011) Purging and isolating pluripotent cells, "sweet" dreams become true?
Cell Res. 21(11): 1526-7.
Menendez S, Camus S, Herreria A, Paramonov I, Batlle Morera L, Collado M, Pekarik V, Maceda I, Edel M, Consiglio A, Sanchez A, Li H, Serrano M, Izpisúa Belmonte JC. (2011) Increased dosage of tumor suppressors limits the tumorigenicity of iPS cells without affecting their pluripotency.
Aging Cell, Oct 10. [Epub ahead of print]
Montserrat N, de Oñate L, Garreta E, González F, Adamo A, Eguizábal C, Häfner S, Vassena R, Izpisúa Belmonte JC. (2011) Generation of feeder free pig induced pluripotent stem cells without Pou5f1.
Cell Transplant, Sep 23. [Epub ahead of print]
Yasuhiko Kawakami, Merce Marti, Hiroko Kawakami, Junji Itou, Thu Quach, Austin Johnson, Setsuko Sahara, Dennis D. M. O’Leary, Yasushi Nakagawa, Mark Lewandoski, Samuel Pfaff, Sylvia M. Evans and Juan Carlos Izpisúa Belmonte. Islet1-mediated activation of the beta-catenin pathway is necessary for hindlimb initiation in mice.
Development 138: 4465-4473.
Sanchez-Danes A, Consiglio A, Richaud Y, Rodriguez-Piza I, Dehay B, Edel M, Bove J, Memo M, Vila M, Raya A, Izpisua Belmonte JC. Efficient generation of A9 midbrain dopaminergic neurons by lentiviral delivery of LMX1A in human embryonic stem cells and iPS cells.
Human Gene Therapy Aug 30. [Epub ahead of print]
Terme JM, Sese B, Millan-Arino L, Mayor R, Izpisúa Belmonte JC, Barrero MJ, Jordan A. Histone H1 variants are differentially expressed and incorporated into chromatin during differentiation and reprogramming to pluripotency.
J Biol Chem. 286(41): 35347-57.
Panopoulos AD, Izpisúa Belmonte JC. Anaerobicizing into pluripotency.
Cell Metab 14(2): 143-4.
Danielle A. Murphy, Begoña Diaz, Paul A. Bromann, Jeff H. Tsai, Yasuhiko Kawakami, Jochen Maurer, Rodney A. Stewart, Izpisúa Belmonte JC, Sara A. Courtneidge. A Src-Tks5 Pathway Is Required for Neural Crest Cell Migration during Embryonic Development.
PLoS ONE 6(7): e22499.
Rita Vassena, Stéphanie Boué, Eva González-Roca, Begoña Aran, Herbert Auer, Anna Veiga and Izpisúa Belmonte JC. Waves of early transcriptional activation and pluripotency program initiation during human preimplantation development.
Development 138(17): 3699-709.
Eguizabal C, Montserrat N, Vassena R, Barragan M, Garreta E, Garcia-Quevedo L, Vidal F, Giorgetti A, Veiga A, Izpisúa Belmonte JC. Complete Meiosis from Human Induced Pluripotent Stem Cells.
Stem Cells 29(8):1186-95.
Fütterer A, Raya A, Llorente M, Izpisúa-Belmonte JC, de la Pompa JL, Klatt P, Martínez-A C. Ablation of Dido3 compromises lineage commitment of stem cells in vitro and during early embryonic development.
Cell Death Differ. 19(1): 132-43.
Liu GH, Suzuki K, Qu J, Sancho-Martinez I, Yi F, Li M, Kumar S, Nivet E, Kim J, Soligalla RD, Dubova I, Goebl A, Plongthongkum N, Fung HL, Zhang K, Loring JF, Laurent LC, Izpisúa Belmonte JC. Targeted Gene Correction of Laminopathy-Associated LMNA Mutations in Patient-Specific iPSCs.
Cell Stem Cell 8(6): 688-94.
Adamo A, Sesé B, Boue S, Castaño J, Paramonov I, Barrero MJ, Izpisúa Belmonte JC. LSD1 regulates the balance between self-renewal and differentiation in human embryonic stem cells.
Nat Cell Biol 13(6): 652-60.
Athanasia D. Panopoulos, Sergio Ruiz, Fei Yi, Aída Herrerías, Erika M. Batchelder, Izpisúa Belmonte JC. Rapid and Highly Efficient Generation of Induced Pluripotent Stem Cells from Human Umbilical Vein Endothelial Cells.
PLoS ONE May, 6(5): e19743.
Giorgetti, A., Fazzina, R., Li, M. and Izpisúa Belmonte, JC. Human cord blood reprogrammed into embryonic-like stem cells.
ISBT Science Series 6: 107-111.
Woods NB, Parker AS, Moraghebi R, Lutz MK, Firth AL, Brennand KJ, Berggren WT, Raya A, Izpisúa Belmonte JC, Gage FH, Verma IM. Brief report: Efficient Generation of Hematopoietic Precursors and Progenitors From Human Pluripotent Stem Cell Lines.
Stem Cells 29(7): 1158-64.
Robles V, Martí M, Izpisúa Belmonte JC. Study of Pluripotency Markers in Zebrafish Embryos and Transient Embryonic Stem Cell Cultures.
Zebrafish 8(2): 57-63.
Barrero MJ, Izpisúa Belmonte JC. iPS cells forgive but do not forget.
Nat Cell Biol, 13(5): 523-5.
Menchón C, Edel MJ, Izpisúa Belmonte JC. The cell cycle inhibitor p27Kip1 controls self-renewal and pluripotency of human embryonic stem cells by regulating the cell cycle, Brachyury and Twist.
Cell Cycle 10(9): 1435-47.
Edel MJ, Menchon C, Andres Vaquero JM, Izpisúa Belmonte JC. A protocol to assess cell cycle and apoptosis in human and mouse pluripotent cells.
Cell Commun Signal. Apr 11 9(1): 8.
Panopoulos AD, Ruiz S, Izpisúa Belmonte JC. iPSCs: Induced Back to Controversy.
Cell Stem Cell Apr 8 8(4): 347-8.
Tiscornia G, Monserrat N, Izpisúa Belmonte JC. Modelling Long QT Syndrome With iPS Cells: Be Still, My Beating Heart ...
Circ Res Mar 18, 108(6): 648-9.
Sancho-Martinez I, Li M, Izpisúa Belmonte JC. Disease Correction the iPSC Way: Advances in iPSC-Based Therapy.
Clin Pharmacol Ther 89(5): 746-9.
Kim S, Izpisúa Belmonte JC. Pluripotency of male germline stem cells.
Mol Cells 32(2): 113-121.
Gore A, Li Z, Fung HL, Young JE, Agarwal S, Antosiewicz-Bourget J, Canto I, Giorgetti A, Israel MA, Kiskinis E, Lee JH, Loh YH, Manos PD, Montserrat N, Panopoulos AD, Ruiz S, Wilbert ML, Yu J, Kirkness EF, Izpisúa Belmonte JC, Rossi DJ, Thomson JA, Eggan K, Daley GQ, Goldstein LS, Zhang K. Somatic coding mutations in human induced pluripotent stem cells.
Nature 471 (7336): 63-7.
Liu GH, Barkho BZ, Ruiz S, Diep D, Qu J, Yang SL, Panopoulos AD, Suzuki K, Kurian L, Walsh C, Thompson J, Boue S, Fung HL, Sancho-Martinez I, Zhang K, Iii JY, Izpisúa Belmonte JC. Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome.
Nature 472(7342): 221-5.
González F, Boué S, Izpisúa Belmonte JC. Methods for making induced pluripotent stem cells: reprogramming à la carte.
Nat Rev Genet 12(4): 231-42.
Barrero MJ, Izpisúa Belmonte JC. Regenerating the epigenome.
EMBO Rep. 12(3): 208-15.
Montserrat N, Garreta Bahima E, Gonzalez F, Gutierrez J, Eguizabal C, Ramos Perez V, Borros S, Izpisua Belmonte JC. Simple generation of human induced Pluripotent stem cells using Poly({beta}-Amino Esters) as non-viral gene delivery system.
J Biol Chem 286(14): 12417-28.
Chris Jopling, Stephanie Boue & Izpisúa Belmonte JC. Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration.
Nature Reviews Molecular Cell Biology 12, 79-89.
Li M, Sancho-Martinez I, Izpisúa Belmonte JC. Cell fate conversion by mRNA.
Stem Cell Res Ther. 2(1): 5.
Isao Oishi, Sungtae Kim, Kyoko Yoshi, Concepcion Rodriguez Esteban and Izpisua Belmonte JC. Cre-LoxP-regulated expression of monoclonal antibodies driven by an ovalbumin promoter in primary oviduct cells.
BMC Biotechnology, Jan 14 11(1): 5.
Montserrat N, Bahima EG, Batlle L, Häfner S, Rodrigues AM, González F, Belmonte JC. Generation of Pig iPS Cells: A Model for Cell Therapy.
J Cardiovasc Transl Res 4(2): 121-30.
Louise C. Laurent, Igor Ulitsky, Ileana Slavin, Ha Tran, Andrew Schork, Robert Morey, Candace Lynch, Julie V. Harness, Sunray Lee, Maria J. Barrero, Sherman Ku, Marina Martynova, Ruslan Semechkin, Vasiliy Galat, Joel Gottesfeld, Izpisúa Belmonte JC, Chuck Murry, Hans S. Keirstead, Hyun-Sook Park, Uli Schmidt, Andrew L. Laslett, Franz-Josef Muller, Caroline M. Nievergelt, Ron Shamir, and Jeanne F. Loring. Dynamic Changes in the Copy Number of Pluripotency and Cell Proliferation Genes in Human ESCs and iPSCs during Reprogramming and Time in Culture.
Cell Stem Cell 8, 106–118.
Ruiz S, Panopoulos AD, Herrerías A, Bissig KD, Lutz M, Berggren WT, Verma IM, Izpisúa Belmonte JC. A High Proliferation Rate Is Required for Cell Reprogramming and Maintenance of Human Embryonic Stem Cell Identity.
Curr Biol, Jan 1121(1): 45-52.

Subir

2010

Tiscornia G and Izpisúa Belmonte JC. MicroRNAs in embryonic stem cell function and fate.
Genes Dev Dec 15, 24(24): 2732-41.
Ruiz S, Brennand K, Panopoulos AD, Herrerias A, Gage FH, Izpisúa Belmonte JC. High-Efficient Generation of Induced Pluripotent Stem Cells from Human Astrocytes.
PLoS ONE Dic; 5(12): e15526.
Barrero MJ, Boué S, Izpisúa Belmonte JC. Epigenetic Mechanisms that Regulate Cell Identity.
Cell Stem Cell, Nov 5, 7(5): 565-70.
Menendez S, Camus S, Izpisúa Belmonte JC. p53: Guardian of reprogramming.
Cell Cycle, Oct 1 9(19):3887-91.
Pere Santamaria, Ignacio Rodríguez-Pizá, Xavier Clemente-Casares, Jun Yamanouchi, Lola Mulero-Perez, Trond Aasen, Angel Raya, Izpisúa Belmonte JC. Turning Human Epidermis Into Pancreatic Endoderm.
Rev Diabet Stud, 7(2): 151-160.
Boué S, Paramonov I, Barrero MJ, Izpisúa Belmonte JC. Analysis of Human and Mouse Reprogramming of Somatic Cells to Induced Pluripotent Stem Cells. What Is in the Plate?
PLoS ONE Sep 17; 5(9). pii: e12664.
Montserrat N, Jopling C, Izpisúa Belmonte JC. Understanding the molecular basis for cardiomyocyte cell cycle regulation: new insights in cardiac regeneration after injury?
Expert Rev Cardiovasc Ther, Aug 8(8): 1043-5.
Masip M, Veiga A, Izpisúa JC, Simón C. Reprogramming with defined factors: from induced pluripotency to induced transdifferentiation.
Mol Hum Reprod 16: 856-868.
Bayes-Genis, A., Soler-Botija, C., Farre, J., Sepulveda, P., Raya, A., Roura, S., Prat-Vidal, C., Galvez, C., Anastasio Montero, J., Buscher, D. and Izpisua Belmonte, JC. Identification of a novel progenitor cell population from adult human cardiac adipose tissue with potential for cardiac repair.
Journal of Molecular and Cellular Cardiology 49: 771-780.
Isaacs MJ, Kawakami Y, Allendorph GP, Yoon B, Izpisúa Belmonte JC, and Choe S. Bone morphogenetic protein-2 and -6 heterodimer illustrates the nature of ligand-receptor assembly.
Molecular Endocrinology, Jul 24(7): 1469-77.
Edel, M. and Izpisúa Belmonte, JC. The cell cycle and pluripotency: Is there a direct link?
Cell Cycle 9: 2694-2695.
Valera E, Isaacs MJ, Kawakami Y, Izpisúa Belmonte JC, Choe S. BMP-2/6 heterodimer is more effective than BMP-2 or BMP-6 homodimers as inductor of differentiation of human embryonic stem cells.
PLoS One Jun 17; 5(6): e11167.
Sleep E, Boué S, Jopling C, Raya M, Raya A, Izpisúa Belmonte, JC. Transcriptomics approach to investigate zebrafish heart regeneration.
J Cardiovasc Med (Hagerstown) May, 11(5): 369-80.
Giorgetti A, Montserrat N, Rodriguez-Piza I, Azqueta C, Veiga A, Izpisúa Belmonte, JC. Generation of induced pluripotent stem cells from human cord blood cells with only two factors: Oct4 and Sox2.
Nature Protocols 5(4): 811-20.
Raya, A, Rodriguez-Piza, I, Navarro, S, Richaud, Y, Guenechea, G, Sanchez-Danes, A, Consiglio, A, Bueren, J and Izpisúa Belmonte, JC. A protocol describing the genetic correction of somatic human cells and subsequent generation of iPS cells.
Nature Protocols 5(4): 647-60.
Chris Jopling, Eduard Sleep, Marina Raya, Mercè Martí, Angel Raya & Izpisúa Belmonte JC. Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation.
Nature Mar 25; 464 (7288): 606-9.
Michael J. Edel, Cristina Menchón, Sergio Menéndez, Antonella Consiglio, Angel Raya, and Izpisúa Belmonte JC. Rem2 GTPase maintains survival of human embryonic stem cells as well as enhancing reprogramming by regulating p53 and cyclin D1.
Genes Dev 24: 561-573.
Sugii S, Kida Y, Kawamura T, Suzuki J, Vassena R, Yin YQ, Lutz MK, Berggren WT, Izpisúa Belmonte JC, Evans RM. Human and mouse adipose-derived cells support feeder-independent induction of pluripotent stem cells.
Proc Natl Acad Sci USA. Feb 23, 107(8): 3558-63.
Christen, B, Robles, V, Raya, M, Paramonov, I and Izpisúa Belmonte JC. Regeneration and reprogramming compared.
BMC Biol. Jan 20; 8:5.
Shigeki Sugiia, Yasuyuki Kida, Teruhisa Kawamura, Jotaro Suzuki, Rita Vassena, Yun-Qiang Yin, Margaret K. Lutz, W. Travis Berggren, Izpisúa Belmonte JC, and Ronald M. Evans. Human and mouse adipose-derived cells support feeder-independent induction of pluripotent stem cells.
PNAS Feb 23; 107(8): 3558-63.
Aasen, T. and Izpisúa Belmonte JC. Isolation and cultivation of human keratinocytes from skin or plucked hair for the generation of induced pluripotent stem cells.
Nature Protocols 5(2): 371-82.
Tramullas, M., Diaz, A., San-Emeterio, E.P., Morchon, N., Lantero, A., Merino, D., Buscher, D., Merino, R., Hurle, J.M., Izpisúa Belmonte JC and Hurle, M. BAMBI (bone morphogenetic protein and activin membrane-bound inhibitor) reveals the involvement of the transforming growth factor-beta family in pain modulation.
Journal of Neuroscience Jan 27; 30(4): 1502-11.
Mizrak, S.C., Chikhovskaya, J.V., Sadri-Ardekani, H., van Daalen, S., Korver, C.M., Hovingh, S.E., Roepers-Gajadien, H.L., Raya, A., Fluiter, K., de Reijke, Th.M., de la Rosette, J.J.M.C.H., Izpisúa Belmonte JC, van der Veen, F., de Rooij, D.G. and van Pelt, A.M.M. Embryonic Stem Cell-like Cells Derived from Adult Human Testis.
Human Reproduction, Jan 25(1): 158-67.
Rodriguez-Piza, I., Richaud-Patin, Y., Vassena, R., Gonzalez, F., Barrero, M.J., Veiga, A., Raya, A. and Izpisúa Belmonte JC. Reprogramming of human fibroblasts to induced pluripotent stem cells under xeno-free conditions.
Stem Cells, Jan 28(1): 36-44.
Aran B, Rodriguez-Pizà I, Raya A, Consiglio A, Muñoz Y, Barri PN, Izpisúa Belmonte JC, Veiga A. Derivation of human embryonic stem cells at the Center of Regenerative Medicine in Barcelona.
In Vitro Cellular & Developmental Biology - Animal, Apr 46(3-4): 356-66.

Subir

2009

Ibanes, M. and Izpisúa Belmonte JC. Left-right asymmetry determination.
Wiley Interdisciplinary Reviews: Systems Biology and Medicine. Sept/Oct: 210-219.
B.Aran, A.Veiga, Izpisúa Belmonte JC. Células madre pluripotentes
Revista Arbor. In press.
Stewart, S., Tsun, Z.Y. and Izpisúa Belmonte JC. A histone demethylase is necessary for regeneration in zebrafish.
PNAS 106(47): 19889-19894.
Giorgetti, A., Montserrat, N., Aasen, T., Rodriguez-Piza, I., Vassena, R., Gonzalez, F., Boue, S., Barrero, M.J., Aran Corbella, B., Raya, A., Torrebadella, M., Veiga, A. and Izpisúa Belmonte JC. Generation of induced pluripotent stem cells from cord blood using OCT4 and SOX2.
Cell Stem Cell. 5:353-357.
Izpisúa Belmonte JC, Ellis, J., Hochedlinger, K. and Yamanaka, S. Induced pluripotent stem cells and reprogramming: seeing the science through the hype.
Nature Reviews Genetics 10: 878-883.
Kawamura, T., Suzuki, J., Wang, Y.V., Menendez, S., Batlle, L., Wahl, G. and Izpisúa Belmonte JC. Linking the p53 tumour suppressor pathway to somatic cell reprogramming.
Nature 460: 1140-1144.
Kan, N., Junghans, D. and Izpisúa Belmonte JC. Compensatory growth mechanisms regulated by BMP and FGF signaling pathways mediate liver regeneration in zebrafish after partial hepatectomy.
FASEB 23: 3516-3525.
Raya, A., Rodriguez-Piza, I., Guenechea, G., Vassena, R., Navarro, S., Barrero, M.J., Consiglio, A., Rio, P., Sleep, E., Tiscornia, G., Garreta, E., Aasen, T., Veiga, A., Verma, I., Bueren, J. and Izpisúa Belmonte JC. Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells.
Nature 460 (7251): 53-9.
Kelber, J.A., Panopoulos, A.D., Shani, G., Booker, E.C., Izpisúa Belmonte JC, Vale, W.W. and Gray, P.C. Blockade of Cripto binding to cell surface GRP78 inhibits oncogenic Cripto signaling via MAPk/PI3K and Smad2/3 pathways.
Oncogene 28: 2324-2336.
Gonzalez, F., Barragan Monasterio, M., Tiscornia, G., Montserrat Pulido, N., Vassena, R., Batlle Morera, L., Rodriguez Piza, I. and Izpsiua Belmonte JC. Generation of mouse induced pluripotent stem cells by transient expression of a single non-viral polycistronic vector.
PNAS 106(22): 8918-8922.
Beck, C., Izpisúa Belmonte JC and Christen, B. Beyond Early Development: Xenopus as an emerging model for the study of regenerative mechanisms.
Developmental Dynamics. 238(6): 1226-48.
Jopling, C. and Izpisúa Belmonte JC. Cilia-Where Two Wnts Collide.
Zebrafish 6(1): 15-19.
Fink, M., Chu, A., Ruiz-Lozano, P., Callol, C., Izpisúa Belmonte JC, Giles, W., Bodmer, R. and Ocorr, K. A new method for detection and quantification of heartbeat parameters in Drosophila, zebrafish, and embryonic mouse hearts.
Biotechniques 46: 101-113.
Rojas-Muñoz, A., Rajadhyksha, S., Gilmour, D., van Bebber, F., Rodríguez-Esteban, C., Nüsslein-Volhard, C., & Izpisúa Belmonte JC. ErbB2 and ErbB3 regulate amputation-induced proliferation and migation during vertebrate regeneration.
Developmental Biology 327: 177-190.
Raya, A., Rodriguez-Piza, I., Aran, B., Consiglio, A., Barri, P., Veiga, A., and Izpisúa Belmonte JC. Generation of cardiomyocytes from new human embryonic stem cell lines derived from poor-quality blastocysts.
73rd Cold Spring Harbor Laboratory Symposium. 73:1-9.
Raya, A and Izpisúa Belmonte JC. Stem Cell Research in Spain: If Only They Were Windmills.
Cell Stem Cell 4(6): 483-486.

Subir

2008

Kawakami, Y., Uchiyama, Y., Rodriguez Esteban, C., Toshiaki, I., Kawakami, H., Marti, M., Kmita, M., Monaghan-Nicols, P., Nishinakamura, R. and Izpisúa Belmonte JC. Sall genes regulate region specific morphogenesis in the limb by modulating Hox activities.
Development 136: 585-594.
Stubbs, J., Oishi, I., Izpisúa Belmonte JC and Kintner, C. The Forkhead protein, FoxJ1, specified node-like cilia in Xenopus and Zebrafish embryos.
Nature Genetics. 40:1454-1460.
Aasen, T., Raya, A., Barrero, M.J., Garreta, E., Consiglio, A., Gonzalez, F., Vassena, R., Bilic, J., Pekarik, V., Tiscornia, G., Edel, M., Boue, S. and Izpisúa Belmonte JC. Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes.
Nature Biotechnology. 26:1276-1284.
Raya, A. and Izpisúa Belmonte JC. Insights into the establishment of left-right asymmetries in vertebrates.
BDRC: Embryo Today. 84(2):81-94.
Ibanes, M and Izpisúa Belmonte JC. Theoretical and experimental approaches to understand morphogen gradients.
Nature Molecular Systems Biology. 4:176.
Pekarik, V. and Izpisúa Belmonte JC. NFIX-One Gene, Two Knockouts, Multiple Effects.
Journal of Biology. 7:29.
Kurpios, N.A., Ibanes, M., Davis, N.M., Lui, W., Katz, T., Martin, J.F., Izpisúa Belmonte JC and Tabin, C.J. Directional gut looping is mediated by changes in the extracellular matrix and in cell:cell adhesion.
PNAS. 105:8499-8506.
Moreno, T.A., Jappelli, R., Brenner, S., Izpisúa Belmonte JC, and Kintner, C. Retinoic Acid Regulation of the Mesp-Ripply Feedback Loop During Vertebrate Segmental Patterning.
Developmental Biology. 315:317-330.
Suzuki, A., Sayaka, S., Buscher, D., Izpisúa Belmonte JC, and Taniguchi, H. Tbx3 controls hepatic stem cell fate in liver development by suppressing p19ARF expression.
Development. 135:1589-1595
Garcia-Gonzalo, F.R. and Izpisúa Belmonte JC. Albumin-associated Lipids Regulate Human Embryonic Stem Cell Self-Renewal.
PLoS ONE, Jan 2; 3(1): e1384.
Rodríguez-León J, Rodríguez Esteban C, Martí M, Santiago-Josefat B, Dubova I, Rubiralta X, Izpisúa Belmonte JC. (2008) Pitx2 regulates gonad morphogenesis.
PNAS 105(32):11242-7.
Barrero, M.J. and Izpisua Belmonte J.C. Epigenetic Mechanisms Controlling Mesodermal Specification. StemBook, doi/10.3824/stembook.1.9.1
StemBook, ed (Harvard)

Subir

2007

Allendorph, G.P., Isaacs, M.J., Kawakami, Y., Izpisúa Belmonte JC, Choe, S. BMP-3 and BMP-6 Structures Illuminate the Nature of Binding Specificity with Receptors.
Biochemistry. 46:12238-12247.
Stewart, S., Rojas-Munoz, A., and Izpisúa Belmonte JC. Bioelectricity and epimorphic regeneration.
Bioessays. 29(11):1133-1137.
Sahara, S., Kawakami, Y., Izpisúa Belmonte JC, O'Leary, D.D.M. Dual roles of Sp8 on cortical area patterning for anterior or posterior identities.
Neuronal Development, 2:10.
Ribeiro, R., Kawakami, Y., Buscher, D., Raya, A., Rodriguez-Leon, J., Morita, M., Rodriguez Esteban, C., Izpisúa Belmonte JC. Tbx2 and Tbx3 regulate the dynamics of cell proliferation during heart regionalization and looping.
PLoS One, Apr 25; 2(4): e398.
Rojas-Munoz, A., Bernad Miana, A., and Izpisúa Belmonte JC. El pez cebra:la navaja suiza de la biologia.
Investigacion y Ciencia. 366:62-69.
Zuzarte-Luis, V., Montero, J.A., Kawakami, Y., Izpisúa Belmonte JC, and Hurle, J. Lysosomal cathepsins in embryonic programmed cell death.
Developmental Biology. 301:205-217.
Matsui, T., Raya, A., Callol, C., Kawakami, Y., Oishi, I., Rodriguez-Esteban, C., and Izpisúa Belmonte JC. Miles apart-mediated regulation of cell-Fibronectin interaction is required for proper myocardial migration in zebrafish.
Nature Clinical Practice Cardiovascular Medicine. 4:S77-S82.

Subir

2006

Kawakami, Y., Rodriguez Esteban, C., Raya, M., Kawakami, H., Marti, M., Dubova, I., and Izpisúa Belmonte JC. Wnt/ß-catenin signaling regulates vertebrate limb regeneration.
Genes and Development. 20:3232-3237.
Kawakami, Y., Rodriguez-Leon, J., Izpisúa Belmonte JC. The role of TGFßs and Sox9 during limb chondrogenesis.
Current Opinion in Cell Biology. 18:723-729.
Oishi, I., Kawakami, Y., Raya, A., Callol-Massot, C., Izpisúa Belmonte JC. Regulation of primary cilia formation and left-right patterning in zebrafish by duboraya, a novel mediator of non-canonical Wnt signaling.
Nature Genetics. 38:1316-1322.
Ibanes, M., Rasskin-Gutman, D., Kawakami, Y., and Izpisúa Belmonte JC. Cell lineage transport: a mechanism for molecular gradient formation.
Nature Molecular Systems Biology. 2:57.
Suzuki, A.,Raya, A., Kawakami, Y., Morita, M., Matsui, T., Nakashima, K., Gage, F.H.,Rodriguez-Esteban, C., and Izpisúa Belmonte JC. Nanog binds to Smad1and blocks BMP-induced differentiation of embryonic stem cells.
PNAS 103: 10294-10299.
Soler-Botija,C., Cervera, R.P., Oishi, I., Raya, R.M., Dubova, I., Rodriguez-Esteban, C., Izpisúa Belmonte JC. Understanding embryonic heart development as atool for cardiac cell based therapy.
Annals of Pediatrics 64: 15-22.
Weninger,W.J., Geyer, S.H., Mohun, T.J., Rasskin-Gutman, D., Matsui, T., Ribeiro, I.,Costa, L., Izpisúa Belmonte JC, Muller, G. B. High resolutionepiscopic microscopy: a rapid technique for high detailed 3D analysis of geneactivity in the context of tissue architecture and morphology.
Anatomy and Embryology 211: 213-221.
Raya, A., Izpisúa Belmonte JC. Vertebrate left-right asymmetry: a convergence ofdivergences.
Nature Reviews Genetics 7: 283-293.
Suzuki, A.,Raya, A., Kawakami, Y., Morita, M., Matsui, T., Nakashima, K., Gage, F.H.,Rodriguez-Esteban, C., Izpisúa Belmonte JC. Maintenance of embryonicstem cell pluripotency by Nanog-mediated reversal of mesoderm specification.
Nature Clinical Practice Cardiovascular Medicine 3: S114-S122.
Leusch, H., Chanda,S.K., Raya, R.M., DeJesus, P.D., Orth, A.P. Walker, J.R., Izpisúa Belmonte JC, Schultz, P. A functional genomics approach to the mode of actionof apratoxin A.
Nature Chemical Biology 2: 158-167.

Subir

2005

Merki, E., Zamora, M., Raya, A., Kawakami, Y., Zhang, X., Burch, J., Kubalak, S., Kaliman, P., Izpisúa Belmonte JC, Chien, K., Ruiz-Lozano, P. Epicardial RXRa is required for myocardial growth and coronary artery formation.
PNAS 102: 18455-18460.
Okada, Y.,Takeda, S., Tanaka Y., Izpisúa Belmonte JC, and Hirokawa, N. Mechanism of Ciliated Organ Flow: a Conserved Symmetry Breaking Event inLeft-Right Axis Determination.
Cell 121: 633-644.
Kawakami,Y., Raya, A., Raya, R.M., Rodriguez-Esteban, C., Izpisúa Belmonte JC. Retinoic acid signaling links left-right asymmetric patterning andbilaterally symmetric somitogenesis in the zebrafish embryo.
Nature May
12; 435(7039): 165-71.
Correa, R.,Matsui, T., Tergaonkar, V., Rodriguez-Esteban, C., Izpisúa Belmonte JC, Verma, I. Zebrafish IkB kinase 1 (Ikk1) negatively regulates NF-kBactivity.
Current Biology 15: 1291-1295.
Da FontouraCosta, L., Travencolo, B.A.N., Azeredo, A., Beletti, M.E., Rasskin-Gutman, D.,Sternik, G., Izpisúa Belmonte JC, Ibanes, M., and Muller, G. A NovelFiel Approach to 3D Gne Expression Pattern Characterization.
Applied PhysicsLetters 86: 143901-143903.
Francisco-Morcillo,J., Sanchez-Calderon, H., Kawakami, Y., Izpisúa Belmonte JC, Hidalgo-Sanchez, M., Martin-Partido, G. Expression of Fgf19 in thedeveloping eye.
Developmental Brain Research 156: 104-109.
Kawakami,Y., Tsuda, M., Takahashi, S., Taniguchi, N., Rodriguez-Esteban, C., Zemmyo, M.,Furumatsu, T., Lotz, M., Izpisúa Belmonte JC and Asahara, H. Transcriptional co-activator PGC-1 regulates chondrogenesis via associationwith Sox 9.
PNAS 102: 2414-2419.
Matsui, T.,Raya, A., Kawakami, Y., Callol, C., Capdevila, J., Rodriguez-Esteban, C., and Izpisúa Belmonte JC. Non-canonical Wnt signaling regulates midlineconvergence of organ primordia during zebrafish development.
Genes and Development 19: 164-175.
Buceta, J., Ibanes, M., Rasskin-Gutman,D., Okada, Y., Hirokawa, N., and Izpisúa Belmonte JC. Nodal CiliaDynamics and the Specification of the Left/Right Axis in Early EmbryoDevelopment.
Biophysical Journal 89: 2199-2209.

Subir

2004

Rasskin-Gutman, D. and Izpisúa Belmonte JC. Embryos at the core of life,
Development 130: 5564-5566.
Raya, A., Consiglio, A., Kawakami, Y.,Rodriguez-Esteban, C., and Izpisúa Belmonte JC. The zebrafish asa model of heart regeneration.
Cloning and Stem Cells 6(4): 345-351.
Kawakami, Y., Rodriguez Esteban, C.,Matsui, T., Rodriguez-Leon, J., Kato, S. and Izpisúa Belmonte JC. Sp8 and Sp9 regulate Fgf8 expression and limb outgrowth in vertebrateembryos.
Development 31: 4763-4774.
Raya, A. and Izpisúa Belmonte JC. Unveiling the establishment of left-rightasymmetry in the chick embryo.
Mech. Dev 121: 1043-1054.
Kang, J.S., Oohashi, T., Kawakami, Y.,Bekku, Y., Izpisúa Belmonte JC and Ninomiya, Y. Characterization ofdermacan, a novel zebrafish lectican gene, expressed in dermal bones.
Mechanisms of Development 121(3): 301-312.
Huang Q, Raya A, DeJesus P, Chao SH,Quon KC, Caldwell JS, Chanda SK, Izpisúa Belmonte JC, Schultz PG. Identification of p53 regulators by genome-wide functional analysis.
Proc. Natl. Acad. Sci. USA 101(10): 3456-3461.
Correa, R.,Tergaonkar, V., Ng, J., Izpisúa Belmonte JC, and Verma, I. Notochorddifferentiation by the T-box gene ntl in zebrafish is regulated by NFkb.
Molecular Cell Biology 24(12): 5257-5268.
Raya, A. and Izpisúa Belmonte JC. Sequential transfer of left-rightinformation during vertebrate embryo development. Curr. Op.
Genes and Development 14: 575-581.
Rasskin-Gutman, D. and Izpisúa Belmonte JC. Theoretical morphology developmentalasymmetries.
BioEssays 26(4): 405-412.
Saez, E., Rosenfeld, J., Livolsi, A.,Lombardo, E., Olson, P., Nelson,M., Banayo, E., Cardiff, R.D., Izpisúa Belmonte JC and Evans, R.M. PPARg signaling exacerbates mammary gland tumor development.
Genes and Development 18(5): 528-540.
Timmerman, L.A., Grego-Bessa, J.,Bertrán, E., Pérez-Pomares, J.M., Diez, J., Aranda, S., Palomo, S., Raya, A., McCormick, F., Izpisúa Belmonte JC and de la Pompa, J.L. Notchpromotes epithelial-mesenchymal transitions during heart development andtransformation.
Genes and Development 18(1): 99-115.
Raya, A., Kawakami, Y., Rodriguez-Esteban,C., Ibañes, M., Rasskin-Gutman, D., Rodriguez-León, J., Büscher, D., Feijó, J.A. and Izpisúa Belmonte JC. Notch activity acts as asensor for extracellular calcium during vertebrate left-rightdetermination.
Nature 427: 121-128.

Subir

2003

Raya, A., Koth, C.M., Büscher, D.,Kawakami, Y., Itoh, T., Raya, R.M., Sternik, G., Tsai, H.-J., Rodriguez-Esteban, C. and Izpisúa Belmonte JC. Activation of Notchsignaling pathway precedes heart regeneration in zebrafish.
Proc. Natl.Acad. Sci. USA, Special Supplement on Stem Cells and the Future of Regenerative Medicine 100: 11889-11895.
Groppe, J., Greenwald, J., Wiater, E.,Rodriguez-Leon, J., Economides, A.N., Kwiatkowski, W., Baban, K., Affolter, M., Vale, W.W., Izpisúa Belmonte JC and Choe, S. Structural basis ofBMP signaling inhibition by Noggin, a novel twelve-membered cystine knotprotein.
The Jnl. of Bone and Joint Surgery 85-A, Suppl. 3: 52-58.
Raya, A., Kawakami, Y.,Rodriguez-Esteban, C., Büscher, D., Koth, C.M., Itoh, T., Morita, M.,Raya, R.M., Dubova, I., Grego Bessa, J., de la Pompa, J.L. and Izpisúa Belmonte JC. Notch activity induces Nodal expression andmediates the establishment of left-right asymmetry in vertebrate embryos.
GenesDev. 17: 1213-1218.
Kawakami, Y., Rodriguez-Leon, J., Koth,C.M., Büscher, D., Itoh, T., Raya, A., Ng, J.K., Rodriguez Esteban, C.,Takahashi, S., Henrique, D., Schwarz, M.F., Asahara, H. and Izpisúa Belmonte JC. MKP3 mediates the cellular response to FGF8signalling in the vertebrate limb.
Nature Cell Biology 5: 513-519.

Subir

2002

Groppe, J., Greenwald, J., Wiater, E.,Rodriguez-Leon, J., Economides, A.N., Kwiatkowski, W., Affolter, M., Vale, W.W., Izpisúa Belmonte JC and Choe, S. Structural basis of BMPsignalling inhibition by the cystine knot protein Noggin.
Nature 420: 636-642.
Izpisúa Belmonte JC. The limb identitygene Tbx5 promotes limb initiation by interacting with Wnt-2band Fgf-10.
Development 129: 5161-5170.
Ng, J., Kawakami, Y., Büscher, D., Raya,A., Itoh, T., Koth, C., Rodríguez Esteban, C., Rodriguez Leon, J., Garrity, D.M., Fishman, M.C. Hurle, J.M. and Izpisúa Belmonte JC. (Ed.).
Limb Development, Special Issue.
Intl.Jnl. of Dev. Biol., Volume 46, Issue No. 7.
Diaz Trelles, R., Rodriguez Leon, J., Kawakami, Y., Simoes, S. and Izpisúa Belmonte JC. Expression of thechick vascular endothelial growth factor D gene during limbdevelopment.
Mechanisms of Development 116: 239-242.

Subir

2001

Capdevila, J. and Izpisúa Belmonte JC. Patterning mechanisms controlling vertebrate limb development.
Ann. Rev. Cell Dev. Biol. 17: 87-132.
Rodriguez-Esteban, C., Raya, A.,Capdevila, J. and Izpisúa Belmonte JC. ¿Cómo distingue el cuerpo la izquierda de la derecha?
Investigacion y Ciencia 300: 62-69.
Mukhopadhyay, M., Shtrom, S.,Rodriguez-Esteban, C., Chen, L., Tsukui, T., Gomer, L., Dorward, D.W.,Glinka, A., Grinberg, A., Huang, S.-P., Niehrs, C., Izpisúa Belmonte JC and Westphal, H. Dickkopf1 is required for embryonic headinduction and limb morphogenesis in the mouse.
Developmental Cell 1: 423-434.
Tavares, A.T., Izpisúa Belmonte JC and Rodriguez-Leon, J. Developmental expression of chick Twistand its regulation during limb patterning.
Intl. Jnl. of Dev.Biol. 45: 707-713.
Rodriguez-Esteban, C., Capdevila, J., Kawakami, Y. and Izpisúa Belmonte JC. Wnt signaling and PKAcontrol Nodal expression and left-right determination in the chickembryo.
Development 128: 3189-3195.
Sharma, K. and Izpisúa Belmonte JC. Development of the limb neuromuscular system.
Curr. Opin. CellBiol. 13: 204-210.
Kawakami, Y., Capdevila, J., Büscher,D., Itoh, T., Rodriguez-Esteban, C., and Izpisúa Belmonte JC. Wnt signals control FGF-dependent limb initiation and AER induction in thechick embryo.
Cell 104: 891-900.

Subir

2000

Capdevila, J. and Izpisúa Belmonte JC. Perspectives on the evolutionary origin of tetrapod limbs.
Jnl.of Exp. Zool 288: 287-303.
Ruiz-Lozano, P., Ryan, A.K. and Izpisúa Belmonte JC. Left-right axis determination.
Trends inCardiovascular Med 10: 258-262.
Liang, J.O., Etheridge,A., Hantsoo, L., Rubinstein, A.L., Nowak, S.J., Izpisúa Belmonte JC, and Halpern, M.E. Asymmetric Nodal signaling in the zebrafish diencephalons positionsthe pineal organ.
Development 127: 5101-5112.
Ryan, A.K. and Izpisúa Belmonte JC. Establishing a left-right axis in the embryo.
IUBMB Life 50: 1-11.
Tavares, A.T., Tsukui, T., and Izpisúa Belmonte JC. Evidence that members of the Cut/Cux/CDP familymay be involved in AER positioning and polarizing activity during chicklimb development.
Development 127: 5133-5144.
Yokoyama, H., Yonei-Tamura, S., Endo,T., Izpisúa Belmonte JC, Tamura, K. and Ide, H. Mesenchymewith Fgf-10 expression is responsible for regenerative capacity in Xenopuslimb buds.
Developmental Biol 219: 18-29.
Capdevila, J., Vogan, K.J., Tabin, C.J.and Izpisúa Belmonte JC. Mechanisms of left-right determinationin vertebrates.
Cell 101: 9-21.
Capdevila, J. and Izpisúa Belmonte JC. Knowing left from right: the molecular basis of lateralitydefects.
Mol. Med. Today 6: 112-118.

Subir

1999

Tamura, K., Yonei-Tamura, S. and Izpisúa Belmonte JC. Differential expression of Tbx4 and Tbx5in Zebrafish fin buds.
Mech. Dev 87: 181-184.
Capdevila, J., Tsukui, T.,Rodriguez-Esteban, C., Zappavigna, V. and Izpisúa Belmonte JC. Control of vertebrate limb outgrowth by the proximal factor Meis2 anddistal antagonism of BMPs by Gremlin.
Mol. Cell 4: 839-849.
Tamura, K., Yonei-Tamura, S. and Izpisúa Belmonte JC. Molecular basis of left-right asymmetry.
Dev.Growth Differ 41: 645-656.
Tsukui, T., Capdevila, J., Tamura, K.,Ruiz-Lozano, P., Rodriguez-Esteban, C., Yonei-Tamura, S., Magallon, J.,Chandraratna, R.A.S., Chien, K., Blumberg, B., Evans, R.M. and Izpisúa Belmonte JC. Multiple left-right asymmetry defects in Shh-/-mutant mice unveil a convergence of the Shh and Retinoic Acid pathwaysin the control of Lefty-1.
Proc. Natl. Acad. Sci. USA 96: 11376-11381.
Tavares, A., Capdevila, J. and Izpisúa Belmonte JC. Transcription factors during limb development.
Scientific American (Sp. edit.) 4, 30-32.
Lin, C.R., Kioussi, C.,O'Connell, S., Briata, P., Szeto, D., Liu, F., Izpisúa Belmonte JC and Rosenfeld, M.G. Pitx2 regulates lung asymmetry, cardiac positioningand pituitary and tooth morphogenesis.
Nature 401: 279-282.
Rodriguez-Esteban, C.,Capdevila, J., Economides, A.N., Pascual, J., Ortiz, A. and Izpisúa Belmonte JC. The novel Cer-like protein Caronte mediates the establishment ofembryonic left-right asymmetry.
Nature 401: 243-251.
Yamada, G., Nakamura, S., Fukuzaki, K.,Izumi, H., Horai, N., Nagata, R., Minami, T., Tohno, Y., Suzuki, K.,Haraguchi, R., Miyado, K., Toyoda, T., Izpisúa Belmonte JC, Maruyama,I. and Kitajima, I. Dysregulation of trace element composition inovariectomized cynomolgus monkey bones.
Cell. & Mol. Biol 44: 1205-1213.
Garcia-Domingo, D., Leonardo, E.,Grandien, A., Martinez, P., Albar, J.P., Izpisúa Belmonte JC and Martinez-A., C. DIO-1 is a gene involved in onset ofapoptosis in vitro, whose misexpression disrupts limb development.
Proc.Natl. Acad. Sci. USA 96: 7992-7997.
Bach, I.,Rodriguez-Esteban, C., Carriere, C., Bhushan, A., Krones, A., Rose, D.W.,Glass, C.K., Andersen, B., Izpisúa Belmonte JC and Rosenfeld, M.G. RLIM inhibits functional activity of LIM homeodomain transcription factors viarecruitment of the histone deacetylase complex.
Nature Genet 22: 394-399.
Huang, R., Zhi, Q., Izpisúa Belmonte JC, Christ, B. and Ketan, P. Origin and development of theavian tongue muscles.
Anat. Embryol 200: 137-152.
Capdevila, J. and Izpisúa Belmonte JC. Extracellular modulation of the Hedgehog,Wnt and TGF-b signalling pathways during embryonicdevelopment.
Curr. Opin. Genet. Dev 9: 427-433.
Merino, R., Macias, D.,Gañan, Y., Rodriguez-Leon, J., Economides, A.N., Rodriguez-Esteban, C., Izpisúa Belmonte JC and Hurle, J.M. Control of digit formation by activinsignalling.
Development 126: 2161-2170.
Izpisúa Belmonte JC. How thebody tells left from right.
Scientific American 280: 46-51.
Li, Q., Lu, Q., Hwang, J.Y., Büscher,D., Lee, K.-F., Izpisúa Belmonte JC and Verma, I.M. IKK1-deficient mice exhibit abnormal development of skin and skeleton.
Genes Dev 13: 1322-1328.
Rodriguez-Esteban, C., Tsukui, T.,Yonei, S., Magallon, J., Tamura, K. and Izpisúa Belmonte JC. The T-Box genes Tbx4 and Tbx5 regulate limb outgrowth andidentity.
Nature 398: 814-818.
Büscher, D. and Izpisúa Belmonte JC. Muscle development during vertebrate limb outgrowth.
Cell & Tissue Res 296: 131-139.
Rincon-Limas, D.E., Lu, C.-H., Canal, I., Calleja, M., Rodriguez Esteban, C., Izpisúa Belmonte JC and Botas, J. Conservation of the expression and function of apterous orthologsin Drosophila and mammals.
Proc. Natl. Acad. Sci. USA 96: 2165-2170.
Yonei-Tamura, S., Tamura, K., Tsukui, T. and Izpisúa Belmonte JC. Spatially and temporally-restrictedexpression of two T-box genes during zebrafish embryogenesis.
Mech. Dev 80: 219-221.
Szeto, D.P., Rodriguez-Esteban, C., Ryan, A.K., O'Connell, S.M., Liu, F., Kioussi, C., Gleiberman, A.S., Izpisúa Belmonte JC and Rosenfeld, M.G. Role of the Bicoid-related homeodomain factor Pitx1 in specifying hindlimb morphogenesisand pituitary development.
Genes Dev 13: 484-494.
Torok, M.A., Gardiner, D.M., Izpisúa Belmonte JC and Bryant, S.V. Sonic Hedgehog (shh) expressionin developing and regenerating Axolotl limbs.
J. of Exp. Zool 284: 197-206.
Ng, J.K., Tamura, K., Büscher, D. and Izpisúa Belmonte JC. Outgrowth and patterning of the vertebratelimb. Molecular and cellular basis of pattern formation during vertebrate limb development.
Current Topics in Dev. Biol 41: 37-66.

Subir

1998

Takahashi, M., Tamura, K., Büscher, D.,Masuya, H., Yonei-Tamura, S., Matsumoto, K., Naitoh-Matsuo, M., Takeuchi,J., Ogura, K., Shiroishi, T., Ogura, T. and Izpisúa Belmonte JC. The role of Alx-4 in the establishment of anteroposteriorpolarity during vertebrate limb outgrowth.
Development 125: 4417-4425.
Rodriguez-Esteban, C., Schwabe, J.W.R.,De La Peña, J., Rincon-Limas, D.E., Magallon, J., Botas, J. and Izpisúa Belmonte JC. Lhx2, a vertebrate homologue of apterous,regulates vertebrate limb outgrowth.
Development 125: 3925-3934.
Ryan, A., Blumberg, B.,Rodriguez-Esteban, C., Yonei-Tamura, S., Tamura, K., Tsukui, T., De LaPeña, J., Sabbagh, W., Greenwald, J., Choe, S., Norris, D.P., Robertson,E.J., Evans, R.M., Rosenfeld, M.G. and Izpisúa Belmonte JC. Pitx2determines left-right asymmetry of internal organs in vertebrates.
Nature 394: 545-551.
Schwabe, J.W.R., Rodriguez-Esteban, C.and Izpisúa Belmonte JC. Limbs are moving...where are they going?
Trends in Genetics 14: 229-235.
Isaac, A., Rodriguez-Esteban, C., Ryan,A., Altabef, M., Tsukui, T., Patel, K., Tickle, C. and Izpisúa Belmonte JC. Tbx genes and limb identity in chick embryo development.
Development 125: 1867-1875.
Kengaku, M., Capdevila, J., Rodriguez-Esteban, C., De La Peña, J., Johnson, R.L., Izpisúa Belmonte JC and Tabin, C.J. Distinct WNT pathways regulating AER formation and dorsoventral polarity in the chick limb bud.
Science 280: 1274-1277.
Capdevila, J., Rodriguez-Esteban, C. and Izpisúa Belmonte JC. Molecular architecture of the vertebrate limb.
Scientific American 12: 23-37 (Sp. edit.).
Kanegae, Y., Tavares, A.T., Izpisúa Belmonte JC and Verma, I.M. Role of Rel/NF-KB transcription factors during the outgrowth of the vertebrate limb.
Nature 392: 611-614.

Subir

1997

Heanue, T.A., Johnson, R.L., Izpisúa Belmonte JC, Stern, C.D., DeRobertis, E.M. and Tabin, C.J. Goosecoidmisexpression alters the morphology and Hox gene expression of the developing chick limb bud.
Mech. Dev 69: 31-37.
Schwabe, J.W.R.,Rodriguez-Esteban, C., De La Peña, J., Tavares, A., Ng, J., Banayo, E.M., Foys,B., Eshelman, B., Magallon, J., Tam, R. and Izpisúa Belmonte JC. Outgrowth and patterning of the vertebrate limb.
Cold Spring Harbor Symposia on Biology, Vol. LXII: 431-435.
Pfeffer, P., De Robertis, E. and Izpisúa Belmonte JC. Crescent, a novel chick gene encoding a Frizzled-like Cysteine-Rich Domain, is expressed in anterior regionsduring early embryogenesis.
Int. J. Dev. Biol 41(3): 449-458.
Lemaire, L., Roser, T., Izpisúa Belmonte JC and Kessel, M. Segregating expression domains of two goosecoid genes during the transition from gastrulation to neurulationin chick embryos.
Development 124: 1443-1452.
Rodriguez-Esteban, C., Schwabe, J.W.R.,De La Peña, J., Foys, B., Eshelman, B. and Izpisúa Belmonte JC. Radical fringe positions the apical ectodermal ridge at the dorsoventral boundary of the vertebrate limb.
Nature 386: 360-366.

Subir

1996

Rodriguez, C., Kos, R., Macias, D.,Abbott, U. K. and Izpisúa Belmonte JC. Shh, HoxD, Bmp-2, andFgf-4 gene expression during development of the polydactylous talpid2,diplopodia1, and diplopodia4 mutant chick limb buds.
Dev. Genetics 19: 26-32.
Ros, M., Lopez Martinez, A., Simandl, B.K., Rodriguez, C., Izpisúa Belmonte JC, Dahn, R. and Fallon, J. The limb field mesoderm determines initial limb budanteroposterior asymmetry and budding independent of sonic hedgehogor apical ectodermal gene expressions.
Development 122: 2319-2330.
Vogel, A., Rodriguez, C. and Izpisúa Belmonte JC. Involvement of FGF-8 in initiation, outgrowth,and patterning of the vertebrate limb.
Development 122: 1737-1750.
Van der Hoeven, F., Sordino, P., Fraudeau, N., Izpisúa Belmonte JC and Duboule, D. Teleost HoxDand HoxA genes: comparison with tetrapods and functional evolution of the HOXD complex.
Mech. Dev 54: 9-21.
Ogura, T., Alvarez, S., Vogel, A.,Rodriguez, C., Evans, R. and Izpisúa Belmonte JC. Evidence thatShh cooperates with a retinoic acid inducible co-factor to establish ZPA-like activity.
Development 122: 537-542.

Subir

1995

Vogel, A., Rodriguez, C., Warnken W. and Izpisúa Belmonte JC. Dorsal cell fate specified by chick Lmx1during vertebrate limb development.
Nature 378: 716-720.
Hardy, A., Richardson, M. K., Philippa,H., Francis-West, P. H., Rodriguez, C., Izpisúa Belmonte JC, Duprez, D. and Wolpert, L. Gene expression, polarizing activity andskeletal patterning in reaggregated hind limb mesenchyme.
Development 121: 4329-4337.
Sucov, H., Izpisúa Belmonte JC, Gañan, Y. and Evans R. Mouse embryos lacking RXRa are resistantto retinoic-acid-induced limb defects.
Development 121: 3997-4003.
Cohn, M., Izpisúa Belmonte JC, Abud, H., Heath, J. K. and Tickle, C. FibroblastGrowth Factors induce additional limb development from the flank of chick embryos.
Cell 80: 739-746.
Francis-West, P. H., Robertson, K., Ede, D. A., Rodriguez, C., Izpisúa Belmonte JC, Houston, B., Burt, D. W.,Gribbin, C., Brickell, P. M. and Tickle, C. Expression of genesencoding bone morphogenetic proteins and sonic hedgehog in Talpid (ta3)limb buds: their relationships in the signaling cascade involved in limb patterning.
Dev.
Dynamics 203: 187-197.

Subir

1994

Fjose, A., Izpisúa Belmonte JC, Fromental, C. and Duboule, D. Expression of the zebrafish gene hlx-1in the prechordal plate and during CNS development.
Development 120: 71-81.

Subir

1993

Olivo, J., Izpisúa Belmonte JC, Tickle, C., Boulin, C. and Duboule, D. Reconstruction fromserial sections: a tool for developmental biology. Application to Hoxgenes expression in chicken wing buds.
BioImaging 1: 115-158.
Dollé, P., Izpisúa Belmonte JC, Brown, J., Tickle, C. and Duboule, D. Hox genes and the morphogenesis of the vertebrate limb.
Prog. Clin. Biol. Res 383A: 11-20.
Izpisúa Belmonte JC, De Robertis,E., Storey, K. and Stern, C. The homeobox gene goosecoid andthe origin of organizer cells in the early chick blastoderm.
Cell 74: 645-659.

Subir

1992

Morgan, B., Izpisúa Belmonte JC, Duboule, D. and Tabin C. Targeted misexpression of Hox-4.6 in the avian limb bud causes apparent homeotic transformations.
Nature 358: 236-239.
Izpisúa Belmonte JC and Duboule, D. Homeobox genes and pattern formation in the vertebrate limb.
Dev. Biol 152: 26-36.
Bastian, H., Gruss, P., Duboule, D. and Izpisúa Belmonte JC. The murine even-skipped-like gene Evx-2is closely linked to the Hox-4 complex, but is transcribed in the opposite direction.
Mammalian Genome 3: 241-243.
Izpisúa Belmonte JC, Brown, J. M., Crawley, D., Duboule, D. and Tickle, C. HOX-4 gene expression in mouse/chicken heterospecific grafts of signaling regions to limb buds reveals similarities in patterning mechanisms.
Development 115: 553-560.
Renucci, A., Zappavigna, V., Zakany, J., Izpisúa Belmonte JC, Bürki, K. and Duboule, D. Comparison ofmouse and human HOX-4 complexes defines conserved sequences involved in the regulation of Hox-4.4.
EMBO J 11: 1459-1468.
Izpisúa Belmonte JC, Brown, J.M.,Duboule, D. and Tickle, C. Expression of HOX-4 genes in the chickwing links pattern formation to the epithelial-mesenchymal interactions that mediate growth.
EMBO J 11: 1451-1457.
Izpisúa Belmonte JC, Ede, D., Tickle, C. and Duboule, D. The misexpression of posterior HOX-4 genes in talpid(ta3) mutant wings correlates with the absence of anteroposteriorpolarity.
Development 114: 959-963.

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1991

Izpisúa Belmonte JC, Tickle, C.,Dollé, P. and Duboule, D. HOX-4 genes and the molecular basis ofvertebrate limb pattern formation.
Dev. Biol 2: 385-391.
Dollé, P., Izpisúa Belmonte JC, Boncinelli, E. and Duboule, D. The Hox-4.8 gene is localized at the 5' extremity of the HOX-4 complex and is expressed at the posteriorend of the body during development.
Mech. Dev 36(1-2): 3-13.
Dollé, P., Izpisúa Belmonte JC, Brown, J., Tickle, C. and Duboule, D. HOX-4 genes and the morphogenesis of mammalian genitalia.
Genes Dev 5: 1767-1776.
Zappavigna, V., Renucci, A., Izpisúa Belmonte JC, Urier, G., Peschle, C. and Duboule, D. HOX4 genes encode transcription factors with potential auto-andcross-regulatory capacities.
EMBO J 10: 4177-4187.
Izpisúa Belmonte JC, Falkenstein, H., Dollé, P., Renucci, A. and Duboule, D. Murine genes related tothe Drosophila AbdB homeotic genes are sequentially expressed during development of the posterior part of the body.
EMBO J 10: 2279-2289.
Izpisúa Belmonte JC, Tickle, C.,Dollé, P., Wolpert, L. and Duboule, D. Expression of the homeoboxHox-4 genes and the specification of position in chick wing development.
Nature 350: 585-589.

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1990

Izpisúa Belmonte JC, Dollé, P.,Renucci, A., Zappavigna, V., Falkenstein, H. and Duboule, D. Primary structure and embryonic expression pattern of the mouse Hox-4.3homeobox gene.
Development 110: 733-745.

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1989

Dollé, P., Izpisúa Belmonte JC, Falkenstein, H., Renucci, A. and Duboule, D. Coordinate expression of the murine Hox-5 complex homeobox-containing genes duringlimb pattern formation.
Nature 342: 767-772.
Bordoni A, Biagi PL, Parenti Castelli G,Hrelia S, Rossi CA, Lercker G, Izpisúa Belmonte JC, Barber T, Cabo J, a Lenaz G. Effect of a hyperlipidic diet on lipid composition, fluidity, and Na+-K+-ATPase activity of rat erythrocyte membranes.
Membrane Biochem 8: 11-18.
Izpisúa Belmonte JC, Barber T, Cabo J, Hrelia S,Rossi CA, Parenti Castelli G, Lercker G, Biagi PL, Bordoni A, Lenaz G. Lipid composition, fluidity and enzymatic activities of rat liver plasmaand mitochondrial membranes in dietary obese rats. Int. J.
Obesity 13: 531-542.

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